Crocin-Induced Endothelium-Dependent Relaxation in Isolated Rat Aorta
نویسندگان
چکیده
منابع مشابه
Saffron Induced Relaxation in Isolated Rat Aorta via Endothelium Dependent and Independent Mechanisms
Crocus sativus L. (saffron) is a widely used food additive for its color and taste. The hypotensive effects of saffron have been shown in previous studies. The aim of this study was to evaluate the mechanism of vasodilatory effects induced by saffron on isolated rat aorta.To study the vasodilatory effects of saffron aqueous extract (0.5, 1 and 2 mg/mL), isolated rat thoracic aorta rings were co...
متن کاملSaffron Induced Relaxation in Isolated Rat Aorta via Endothelium Dependent and Independent Mechanisms
Crocus sativus L. (saffron) is a widely used food additive for its color and taste. The hypotensive effects of saffron have been shown in previous studies. The aim of this study was to evaluate the mechanism of vasodilatory effects induced by saffron on isolated rat aorta.To study the vasodilatory effects of saffron aqueous extract (0.5, 1 and 2 mg/mL), isolated rat thoracic aorta rings were co...
متن کاملNitric oxide mediated endothelium-dependent relaxation induced by glibenclamide in rat isolated aorta.
OBJECTIVES Glibenclamide was found to act as both a selective ATP-sensitive K(+) channel blocker and a vasorelaxant. The exact mechanisms underlying the relaxant effect of glibenclamide are unknown. The present study was designed to examine the role of endothelium/nitric oxide in glibenclamide-induced relaxation in rat isolated aortic rings. METHODS A combination of experimental approaches in...
متن کاملEndothelium-dependent relaxation in aorta of BB rat.
The study was undertaken to determine whether the phenomenon of endothelium-dependent relaxation was impaired in the spontaneously diabetic BB Wistar rat. Endothelium-dependent relaxation in the aorta of overtly diabetic animals was compared with that in nondiabetic BB rats. The relaxative responses were elicited in vitro to acetylcholine (-8.0 to -5.5 log M) and histamine (-7.0 to -3.0 log M) ...
متن کاملThe evidence for histamine H3 receptor-mediated endothelium-dependent relaxation in isolated rat aorta
The presence of histamine H(3) receptors was evaluated on the rat aorta endothelium. In the presence of pyrilamine (1 nM, 7 nM, 10 nM) or thioperamide (1 nM, 10 nM, 30 nM) the concentration-response curve for histamine-induced (0.1 nM - 0.01 mM) endothelium-dependent rat aorta relaxation was shifted to the right without significant change of the E(max) indicating competitive antagonism by pyril...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Jundishapur Journal of Natural Pharmaceutical Products
سال: 2016
ISSN: 1735-7780,2228-7876
DOI: 10.5812/jjnpp.32801